بررسی الل HLA-DQB1*3 در بیماران مبتلا به آلوپسیا آره آتا
نویسندگان
چکیده مقاله:
Background and Objective: Alopecia Areata (AA) is a multifactorial disease characterized by hair loss especially from the scalp affecting approximately 5.3 million people. Since major histocompatibility complex (HLA) region is considered to be associated with AA susceptibility, the effect of HLA-DQB1*3 allele frequency was investigated in the present study in AA patients and their respective controls. Materials and Methods: This study consisted of 30 patients with AA (13 females and 17 males, with a mean age of 26.3 ±2.28 years) and 15 healthy controls (5 females and 10 males, with a mean age of 30.1 ±1.5). DNA was extracted from blood samples using DNG plus method and PCR-SSP was used to detect HLA-HLA-DQB1*3. Furthermore, association of this HLA allele with some baseline clinical and demographical features was assessed. Results: The frequency of the HLA-DQB1*3 allele was not significantly higher in patients (23.3%) as compared to the controls (26.7%). We found no association with family history, stress, phobia, and onset of the disease in patients with AA) p > 0.05(. Conclusion: Our data do not show a correlation between the HLA-DQB1*3 allele and occurrence of AA in population.
منابع مشابه
بررسی پلی مورفیسم ژن TNF-α(rs1800629) در بیماران مبتلا به آلوپسیا آره آتا
Background and Objective: Alopecia Areata (AA) is characterized by an autoimmune hair loss usually, but not limited to, the scalp, affecting approximately 1-2% of the general population. Although the etiology and pathogenesis of this disease is still unknown, it is known that TNFα-308G/A polymorphism can influence the development of AA. The aim of this study was to investigate TNF-α(rs1800629) ...
متن کاملبررسی ارتباط بین آلل HLA-DQA2 با بیماری آلوپسیا آره آتا
Background and purpose: Alopecia areata (AA), also known as spot baldness, is an autoimmune disease in which hair is lost from some or all areas of the body. Genetic factors are known to play a role in the onset of this disease. The HLA complex genes are primarily involved in AA. In present study, effect of HLA-DQA2 allele frequency was analyzed in Iranian AA patients and control samples. Mate...
متن کاملمقایسهی عملکرد تیرویید در بیماران مبتلا به آلوپسی آره آتا توتالیس، یونیورسالیس با گروه کنترل
Background: Alopecia areata (AA) is a common cause of noncicatricial alopecia that occurs as a patchy, confluent or diffuse pattern. Exact etiologic factor of AA not yet recognized. Among many hypothesis, relationship between AA and autoimmune disease, especially thyroid disorders, was more interesting. The objective of this study was to determine the prevalence of thyroid test disorders in the...
متن کاملبررسی توزیع فراوانی anti-tissue transglutaminase iga در بیماران مبتلا به آلوپسی آره آتا
مقدمه: آلوپسی آره آتا (aa یا alopecia areata) یک بیماری شایع و بدون علامت است که با ریزش سریع مو در یک منطقه مشخص می شود. علت آن هنوز به طور کامل شناخته نشده است. بعضی مطالعات ارتباط بین aa و سلیاک را نشان داده اند. هدف از انجام این مطالعه، مقایسه ی سطح anti-tissue transglutaminase iga (anti-ttg iga) در بیماران مبتلا به aa با گروه شاهد بود. روش ها: این مطالعه، یک مطالعه ی مورد- شاهدی بود که گرو...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 24 شماره 129
صفحات 57- 64
تاریخ انتشار 2017-07
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی برای این مقاله ارائه نشده است
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023